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Joint research is pointed out by the literature as a potentially virtuous cooperation scheme to generate learning in the public sphere and beneficial effects in society. The purpose of this study, based on the Argentine experience in the COVID-19 pandemic, is to analyze the network of capacities, relationships and effects generated, over time, by a series of projects financed by the State in 2010, to clarify the link between learning effects and social effects.

A qualitative methodology focused on the multiple case study method was used. Each case covers joint R&D projects financed 10 years ago by the state that subsequently led to different solutions for COVID-19.

The work identifies a public learning process that integrates both industry’s contributions and the intellectual dimension of economic benefits and their translation into specific capabilities; conceptualizes the capacities accumulation process as a multiplier of social effects (direct and indirect) that emerge as knowledge is reused; identifies the articulation between different schemes as a condition for learning effects and social effects to manifest over time.

An aspect not studied in the literature is addressed, the relationship between the learning process induced by joint research, in terms of capabilities, and the social effects specifically generated over time. This is taking place in a context, such as the COVID-19 pandemic, where calls from the scientific and academic community to promote science–industry cooperation are multiplying.

The purpose of this paper is to show how science-industry R&D cooperation (SIRC) generates effects on the strategy developed by firms to appropriate the benefits of innovations. Given the plurality of cooperation patterns between firms and public R&D institutions and the variety of appropriation mechanisms used by firms to protect generated knowledge or to strengthen their market position, this paper investigates to what extent different forms of cooperation are associated with different effects on appropriation strategy.

As evidence of this, the authors carry out a multiple case study, covering nine biopharmaceutical Argentine firms whose innovation projects are developed in cooperation with public R&D institutions. Using critical dimensions identified by public-private R&D cooperation literature, the paper analyzes the characteristics of cooperation in the cases studied, looking for different patterns. Given the existence of various appropriation mechanisms identified by appropriability literature, the paper analyzes how firms use (or not) those mechanisms within the specific context of jointly generated innovation.

The paper shows that SIRC generates opposing effects on the various appropriation mechanisms used by firms, both challenging and strengthening them. Likewise, the identification of three cooperation patterns in Argentine biopharmaceutical sector, namely, contract R&D, internalization and coordination, allows appreciating how each pattern affects differently the appropriation mechanisms used by firms, being the coordination one, the most functional to the appropriation strategy of firms analyzed.

The arguments presented here are necessarily limited to the biopharmaceutical Argentine sector, which is strategic to the country, for accumulated capabilities in scientific and business aspects. The analysis could be enriched by extending it to other industries with similar innovation characteristics and to other countries, where patents have a similar weight (emerging countries) or a different one (developed countries).

Innovation and public-private collaboration policies may benefit from the analysis presented here, which helps to assess advantages and challenges of different SIRC logics on firms’ appropriation issues and to considerate which aspects allow cooperation and appropriation combining in a more virtuous form.

There is no paper that explicitly examines the effects generated by different SIRC patterns on the appropriation strategy of firms, conceived as a combination of different mechanisms which may include patents but is not limited to them.